We are interested in the dynamic interplay between the gut microbiota and the innate and adaptive immune systems.
Keywords: gut microbiota, immune systems, interplay, germ-free, gnotobiotic mouse models.
Using germ-free and gnotobiotic mouse models our research group aims to understand how exposure to intestinal microbes early in life educates and regulates the developing immune system and how this impacts on susceptibility to immune-mediated diseases such as allergy and autoimmunity. Research into the gut microbiome requires the isolation of a single bacterium in animal models in order to rule out other environmental factors.
While more research is necessary, we are optimistic that new therapies will be developed that harness the power of the gut microbiome. The new International Microbiome Centre (IMC) ’s germ-free facility, will provide the perfect space to investigate gut bacteria. We will be able to study specific gut microbiomes without other environmental variables to consider. This will help us further this research, as well as complete many other studies into the effects of the microbiome.