Our latest publications !

In this study, the authors identified microbial D-lactate, as a modulator of an intravascular immune firewall that protects against the spread of bacterial infections via the bloodstream.
Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four mouse models of cancer! This promising study" identifies a novel microbial metabolite-immune pathway that may be exploited to develop microbial-based adjuvant therapies."
In this intercontinental research effort between Switzerland, Norway, Germany and Canada, Dr. H. Li, colleagues and international collaborators notably Dr. K.D. McCoy, used “localized time-limited exposures of defined doses of single benign microbial taxa in germ-free mice” to “address how the B cell repertoire is shaped by microbiota exposure at mucous membranes or in systemic lymphoid tissues, and how interactions between different exposure sites or subsequent exposures to different taxa affect the outcome”.
Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific TH17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic ...The ability to restrain cardiotoxic T cells through manipulation of the microbiome thereby transforms inflammatory cardiomyopathy into a targetable disease.
Here we report that mice colonized with a combination of bacterial species with specific characteristics is required to inhibit IgE levels... inhibition of IgE induction can be mediated by specific microbes and their associated metabolic pathways and immunogenic properties.
Here we report that mice colonized with a combination of bacterial species with specific characteristics is required to inhibit IgE levels... inhibition of IgE induction can be mediated by specific microbes and their associated metabolic pathways and immunogenic properties.
Through effects on early-life colonization, immune development, and neurodevelopment, the maternal microbiota regulates susceptibility to a number of childhood illnesses and can vertically transmit dysbiosis-mediated pathologies.
Appropriate priming of tolerogenic or effector immune responses is crucial for intestinal homeostasis. Esterhazy et al. (Nature, 2019) reveal how compartmentalization of lymphatic drainage to functionally distinct lymph nodes facilitates the simultaneous induction of tolerogenic and effector responses.
The microbiota plays an important role in regulating both the innate and adaptive immune systems. This review highlight the role of the microbiota in the induction of immune memory with a focus on both adaptive and innate memory as well as vaccine efficacy.

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